Colonic malakoplakia in a pediatric renal transplant recipient case report

Colonic malakoplakia in a pediatric renal transplant recipient case report

Blog Article

Malakoplakia is a rare, chronic granulomatous disease that mainly affects the genitourinary system of immunocompromised adults.It is caused Multi-Tools by a bactericidal deficit in macrophages and, therefore, the treatment includes antimicrobials that reach high concentrations in macrophages.To our knowledge, we present the first case of malakoplakia in a pediatric solid organ transplant recipient.Our patient is a 15-year-old male renal transplant recipient who Acne Treatment presented with recurrent diarrhea.Blood, urine, and gastrointestinal pathogen panel testing were positive for enteroaggregative Escherichia coli.

A colonoscopy revealed diffuse malakoplakia.He had a complete resolution of symptoms with trimethoprim-sulfamethoxazole therapy.Unfortunately, his malakoplakia recurred after 9 months prompting the transition of therapy to oral gentamicin with subsequent remission.Malakoplakia should be considered in the differential of solid organ transplant recipients with recurrent gastrointestinal infections.